The Charlie's Angels co-stars have been pals for decades, growing up together under the Hollywood spotlight, and they are so close, Drew refers to Cameron by the name ‘Poo Poo’.
The 41-year-old made the revelation during a new interview with Marie Claire magazine, in which she casually recounts her friendship with Cameron.
"I've known Poo Poo (Cameron) since I was 14 years old," the former child star said. "We just happened to know each other before her career started, and I was working in a coffeehouse trying to refigure out my life."
She did not expand on her unusual moniker for her friend, but the actresses are known for their playful personalities, so Cameron likely has a funny nickname for Drew, too.
Meanwhile, Drew opened up about her role as a mother to daughters Olive, three, and Frankie, who turns two next month, admitting her home life is a far cry from the glamour of Hollywood.
The star, who is married to Will Kopelman, confesses she typically dresses down with no make-up on whenever she takes her kids to pre-school, but when she finally did make a little effort, she noticed a change in how she was treated.
"I went to parents' night, and I wore some lipstick and concealer, and I thought the people at school looked at me kind of differently," she recalled. "I normally come with acne and Ugg boots, and I thought they were like, 'Oh, that's nice, she made a little bit of an effort.'"
Ironically, Drew owns her own Flower Beauty brand of cosmetics.
Barrymore proves that motherhood is no easy task, even for the stars of tinsel town!