Ashley Greene's dog died when her apartment went up in flames on Friday (22 March).
The Twilight Saga actress' home in a Los Angeles apartment block caught fire with her two dogs inside and while firefighters were able to rescue one of her fox terriers, the other one didn't make it, according to People magazine.
The 26-year-old actress' representative said the cause of the fire is as yet "undetermined".
Los Angeles Fire Department Inspector Johnson told RadarOnline: "We made an aggressive fire attack. Our team saw smoke and fire coming from the third floor. We have reports of two patrons that were burned, so they were treated by the paramedics and sent to the hospital."
10 fire trucks were called to the scene of the seven-story building.
It was recently reported that Ashley is dating Ryan Phillippe after the pair were spotted leaving LA club Vignette Lounge together.
The 26-year-old actress - who has previously dated Joe Jonas and Chace Crawford - previously admitted she struggles to find a relationship because of the nature of the industry, and sometimes thinks moving back to Florida would be her best option.
She said: "Dating is a hard, hard thing when you have this job. Sometimes I wish I could just go back to Florida and, like, date my home-town boyfriend."